International Journal of Computational Linguistics Research Nataša Savic, Zoran Milivojevic, Zoran Velickovic, Darko Brodic 13 1 2022 https://doi.org/10.6025/jcl/2022/13/1/15-22 https://www.dline.info/jcl/fulltext/v13n1/jclv13n1_3.pdf In this work, we have presented the optimization of the parameters of two-parameter Keys kernel and did the Optimization using the spectral domain. The optimization criterion is the condition that the amplitude characteristic is a good approximation of the amplitude characteristic of the ideal interpolation kernel of the form sinx/x. Further, the work presented the experimentally determined optimal value of the kernel parameters using signals.