Journal of Information & Systems Management Mahdi Alhaji Musa, Mohd Shahizan Othman 7 2 2016 Healthcare organizations face several challenges such as providing services efficiently, achieving strategic and operational success, and improving their business processes. They are forced to make these re-engineering not only to compete and prosper, but also to merely survive strong external forces, such as technological breakthroughs. In last few years, one of the recent trend in business paradigm which has gained a lot of is business process re-engineering (BPR). Consequently, the healthcare institutions have to take advantage of using BPR to achieve dramatic improvements in critical, contemporary measures of performance such as cost, quality, service and speed. A lot of factors must be put into consideration for any Healthcare institutions that need to venture into BPR. This paper is intended to examine the BPR critical success factors (CSFs) as perceived by employee. In this study, three main factors related to the BPR CSFs within a Healthcare environment including use of IT, Methods selections and Strategic alignment were identified and measured. The factors were tested by surveying employees of the Sani Abatcha Specialist Hospital, Nigeria. The results revealed that measurement of effectiveness of IT on the BPR is the most critical success factor for BPR implementation.